- The humanization of TBL-100 was conducted by LifeArc under a risk sharing agreement with TAU BIO-LOGIC, with terms that would see LifeArc receive a small royalty on future drug sales. "We are delighted to have contributed to the development of TBL-100, " said Dr Justin Bryans, head of LifeArc's Centre for Therapeutic Discovery. "The collaboration has produced a lead candidate for further development and several good backup molecules offering a combination of excellent biophysical characteristics and thermostability properties, high affinity binding and high expression.
"Successful humanization marks an important milestone in the development of TBL-100, which we believe offers several advantages compared to other anti-tau antibodies and small molecule tau treatments in development, both in terms of safety and improved efficacy," said Daniel G. Chain, PhD, President and CEO of TAU BIO-LOGIC. "We aim to rapidly advance this promising disease-modifying therapeutic agent for patients suffering from AD and PSP since these conditions currently lack effective therapies.
About TAU BIO-LOGIC CORPORATION TAU BIO-LOGIC is a privately held biopharmaceutical company focused on the development of innovative high precision immunotherapies for the treatment of Alzheimer's disease (AD), Supranuclear Palsy (PSP) and related neurodegenerative conditions. The company's lead product is TBL-100 a monoclonal antibody that binds and inhibits the activity of C-terminally truncated tau (tauC3). The humanized antibody has an affinity of 13pM (about 100-fold higher than most marketed therapeutic antibodies have for their targets) and a specificity that is 1000-fold greater than for full length tau (FLT). The high affinity and specificity of the antibody are expected to translate into improved efficacy and safety compared to other tau antibodies currently in development.
About LifeArcLifeArc is a medical research charity with a 25-year legacy of helping scientists and organizations translate their research into treatments and diagnostics for patients. LifeArc turns great science into greater patient impact. The charity brings together a network of partners to tackle specific diseases and directly funds academic and early stage research. So far, LifeArc's work has helped to develop four approved medicines (Keytruda®, Actemra®, Tysabri® and Entyvio®) and a diagnostic test for resistance to carbapenem.
About ADAD is the most common cause of dementia and represents an enormous and growing global public health challenge. It is a uniformly fatal neurodegenerative disorder with no cure or substantially effective treatment. AD currently affects more than 5 million Americans, 7 million Europeans and, in total, about 44 million people worldwide according to the most recent report by the Alzheimer's Association. No disease-modifying treatments have been approved for either the early or late disease stages.
About PSP PSP is a rare and fatal degenerative neurological disorder affecting about 20,000 people in the United States. It causes progressive impairment of balance and walking; impaired eye movement, abnormal muscle tone, speech difficulties, and problems related to swallowing and eating. Affected individuals also frequently experience personality changes and cognitive impairment. Symptoms typically begin after age 60 but can begin earlier. The exact cause of PSP is unknown, and the disease is often initially misdiagnosed as Parkinson's disease. No disease-modifying treatments have been approved for either the early or late disease stages.